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Monday, July 15, 2019

Letter To The Cynic, the University of Vermont's Student Newspaper

     I am a grandson of Paul A. Moody, who was a professor of zoology at the University of Vermont from 1927 to 1973. In 1953, Grandpa served on a UVM committee that was charged with deciding whether Alex Novikoff, a Medical College faculty member, was a communist and should be fired. UVM fired Novikoff. My grandfather dissented. 
     Were he alive today, Grandpa would have been disappointed, if not sickened, to hear that the university has dismissed economics Professor John Summa. 
     For six years starting in 1997, 11 years after his death, I researched the life of my grandfather. The so-called ``Novikoff affair’’ and his role in it was the main target of my research. In Vermont, the troubles for Novikoff, a Russian Jew who migrated to the United States with his parents, began after it was learned that he had, in the 1930s, joined the Communist Party of the United States while on the Brooklyn College faculty. He was a leader of the faculty union there. In 1953 Novikoff was subpoenaed to testify the before U.S. Senate Internal Security Subcommittee. Invoking the Constitution’s Fifth Amendment protection against self-incrimination, Novikoff declined to answer several questions. 
      Mired in the reactionary spirit of the McCarthy Era, a substantial part of the general public was willing to interpret ``pleading the Fifth’’ as an admission of guilt.Yet in a written statement made in May 1953, at age 50, Grandpa wrote that he was convinced that Novikoff did so to protest

 ``inquisitorial methods of investigation, and infringement upon personal liberty and individual freedom.’’
     Nowadays academia is the target of the political right wing; likewise, Novikoff was a man marked by political-fringe McCarthyism. In her book, ``Dark Money,’’ Jane Mayer says that by 2014, the libertarian Koch brothers had funded 283 pro free-market programs at four-year colleges and universities. 
     Paul Amos Moody was no leftist. He opposed the repeal of Prohibition and denounced the New Deal in the letters section of the Burlington Free Press. He voted Republican in every presidential election until 1976, when he voted for Jimmy Carter. Yet when it came time to pass judgment on Novikoff, Grandpa disregarded his political inclination biases to focus on facts. He asserted that Novikoff had not been a communist at UVM, that he would not try to influence students toward communism and that he did not pose a security risk to the United States. 
     Comparing immigrants to ``we rather complacent Americans of native birth,’’ he said they are perhaps
``the more worthy spiritual descendants of…the founding fathers whose first-hand knowledge of the suppression of individual rights prompted the writing of the Fifth Amendment…’’
     References to immigrants, complacent Americans and democracies falling into authoritarianism bring to mind the unmistakable new wave of xenophobia and acts of hatred in the United States. My country's respect for civil political discourse is flagging. Suppression of intellectual freedom will do nothing to make things better. 
     In 1997, I interviewed Merton Lambden, a retired UVM professor of biochemistry. Lambden was a contemporary of Novikoff’s at the university. He told me that the political atmosphere at UVM during the Novikoff affair bothered him so much that every day his stomach churned. All of us should consider the politically motivated hiring and firing of faculty to be, at the very least, stomach-churning.

A Fresh Application of Bigotry

      Somewhere along the line in elementary school, I came across a biography of W.E.B DuBois. I read it and then, as best as I can remember, I didn’t pick up another book on African-American history for perhaps 15 years.

     But that does not mean that I learned nothing more about the subject during that time. At what is now the Amherst-Pelham Regional Middle School, I had a class in which Edward O’Daniel taught us about the Reconstruction period, the black codes and the three-fifths compromise.  We watched ``The Diary of Miss Jane Pittman,’’ and when it was done, Mr. O’Daniel said he didn’t like the program because it made slavery look like paradise.

     When I was 13, I started to learn tunes by Mississippi John Hurt; I liked the way they sounded when my guitar teacher played them. I moved on to Blind Blake, Robert Johnson and Big Bill Broonzy. This requires untold hours of practice. I absorbed with my hands, my ears and my heart the harmony, melody and rhythm of music that had been played by African Americans about 45 years earlier. I still wonder what it would have been like to be one of those musicians and one of the people who heard the songs when the songs were young.
     In 1984, I read ``Let the Trumpet Sound,’’ a King biography by Stephen Oates. Since then I’ve read several books about southern American culture and African-American history. Studying African American history and African American culture is a robust way to understand United States history.
***
     Europe and the United States are ensnared in a dreaded historical pattern. Uncertainty, economic and otherwise, is fueling demagoguery. Among the scapegoats in the 20th century were German Americans, Japanese Americans, Jews, blacks and so-called Communists. During this century, transgender people and Muslims have been added to the list.

     Bigotry is receiving a fresh application of fertilizer. Bigots define peoples and religions as foreign and sinister. Bigots embrace the fallacy that one can commit huge amounts of energy demonizing peoples and religions and, at the same time, understand them. This is impossible because to understand something one must clear the path to understanding. To do that one must put aside the underdeveloped ideas that impede the way. Bigots don’t try to clear the way. Instead, they make a career of insisting that they do. And they do it quite publicly. In Nazi Germany, they did it loudly and often enough to make it easy for Hannah Arendt to observe

``the curious contradiction between the totalitarians’ avowed cynical `realism’ and their conspicuous disdain of the whole texture of reality.’’
     The result, as Geoffrey Chaucer puts it, is something like a cacophony: ``Thus they kept up the jangle of debate/As the illiterate are wont to do/When subtler things are offered to their view/Than their unletterterdness can comprehend/They reach the wrong conclusions in the end.’’

***
     A few years ago I was gratified to see that in one Belchertown, Massachusetts public school classroom the objective was to learn about Islamic religion and culture. I imagine that school personnel looked around, became aware of the suffering of American Muslims and developed a curriculum that would help kids learn about Islam in a responsible location, the classroom. Rather than ``on the streets.’’ That is, from the bigots.

Copyright 2018 Daniel Steven Miller


Saturday, July 13, 2019

Promising Treatments for Depression Stem from Research into Little-Understood Brain Functions

(Commissioned by a Guru.com client, a.k.a. Asshole)

     People with major depression often find themselves crying for no apparent reason; they report feelings of seemingly insurmountable sorrow, like plummeting down a well of worsening despair. Suicide attempts are common.

     Incidences of the debilitating mental illness major depression are spiking worldwide.  From 1992 to 2017, the number of people with depression at all levels of intensity rose from 168 million to 254 million – an increase of 51 percent.

     For years, researchers focused on the neurochemical explanation for depression: Patients had a deficiency of one or more of the three neurotransmitters that affect mood.

     A June 2019 article from the Harvard Medical School states that numerous non-neurologic causes for depression are now understood. Depression can be triggered by stressful life events, medications the patient is already taking, other medical problems, genetic vulnerability.

     Experts are still focusing on neurochemistry -- but on many more than three chemicals. ``There are millions, even billions, of chemical reactions that make up the dynamic system that is responsible for your mood, perceptions, and how you experience life,’’ the Harvard Medical School article states.

     Indeed, when we consider the different extents that depression affects different people of different ages, ethnicities and genders, we can see that depression is not merely a matter of the presence or absence of neurotransmitters.

     In the United States, the epidemic has proven to be especially rough going for women, younger people, native Alaskans and American Indians and whites. According to the National Institute for Mental Health, in the United States in 2017, 5.3 percent of males and 8.7 percent of females were diagnosed with major depression in the last year. Thirteen percent of people aged 18 to 25 had the diagnosis. The percentage for those aged 26 to 49 is 7.7 percent. For everyone aged 50 and over, the figure is 4.7 percent.

     The highest incidence was the 8 percent suffered by American Indians and native Alaskans. A close second were white people, of whom 7.9 percent were diagnosed. The figure for African Americans and Hispanics is 5.4 percent. (This is interesting because it works against the tide of the conventional wisdom that the lives of African Americans and Hispanics are usually much more stressful than those of white people.)

     Also, there are noteworthy global disparities. For instance, in Greenland in 2017, 6.2 percent suffered some degree of depression. The percentages, respectively, were 4.8 in the United States and 3.5 in India.

     The demographic data raise the question of whether researchers could find a course of treatment that would help a significant of people with depression. Would the same therapeutic regimen provide a comparable level of benefit to a 39-year-old white man and a 15-year-old Hispanic girl? How about a middle-aged woman in southern Asia and a teenage boy in the United States?

     As with all mental-health problems, experts recommend a combination of medication and talk therapy to tackle depression. They also recommend that patients pay attention to their daily routines. But these days researchers are looking into new treatments that are based on neurology.

     In March, the U.S. Food and Drug Administration gave the go-ahead to esketamine, the first new anti-depressant to be approved in decades. The drug is a result of research into ketamine, an aesthetic that acts on NMDA receptors, to which researchers had hitherto given relatively little attention. ``Homing in on this channel appears to provide relief from depression that is better, arrives faster, and works in far more people than current drugs,’’ Business Insider reported in December.

     Researchers are also looking into the use of psilocybin. ``Brain scan studies suggest that depression ramps up the activity in brain circuits linked with negative emotions and weakens the activity in circuits linked with positive ones. Psilocybin appears to restore balance to that system,’’ Business Insider reported.

     The work on esketamine, marketed as the nasal spray SPRAVATO, and psilocybin stem from a ``resurgence of interest’’ in therapies that affect parts of the brain that are not targeted by anti-depressant medications now.

     In March 2018, researchers at the Scripps Research Center’s Florida campus announced that they had started to investigate another unexplored area, the brain receptor GPR158. They found that people with a high GPR158 level were susceptible to major depression.

     "The next step in this process is to come up with a drug that can target this receptor," Science Daily quoted top research investigator Kirill Martemyanov as saying.

     The GPR158 research won’t result in a new drug therapy anytime soon, according to the report. "This is really new biology and we still need to learn a lot," Martemyanov said.

     A psilocybin-derived treatment may not arrive for at least another 10 years.

Sources

·        A fresh crop of promising drugs is poised to change the way depression is treated for the first time in decades. Here are the ones to watch in 2019. https://www.businessinsider.com/most-promising-new-depression-drugs-treatments-predictions-2019-2018-12  accessed July 8, 2019

·        Depression: Overview

https://www.nimh.nih.gov/health/topics/depression/index.shtml

accessed July 7, 2019

·        Depression: What Are Signs and Symptoms http://mentalhealth.fitness/learnabout-your-diagnosis/depression/ accessed July 7, 2019

·        Major Depression https://www.nimh.nih.gov/health/statistics/major-depression.shtml accessed July 7, 2019

·        New research points to better way to treat depression https://www.sciencedaily.com/releases/2018/03/180301125040.htm accessed July 9, 2019

·        Our World in Data https://ourworldindata.org/mental-health#depression accessed July 6, 2019

·        What Causes Depression? https://www.health.harvard.edu/mind-and-mood/what-causes-depression accessed July 6, 2019

(c) 2019 Daniel S. Miller